Immunohistochemical Analysis of Salivary Gland Tumors: Application for Surgical Pathology Practice
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概要
- 論文の詳細を見る
Salivary gland tumors are relatively uncommon and there exists a considerable diagnostic difficulty owing to their diverse histological features in individual lesions and the presence of a number of types and variants, in addition to overlapping histological patterns similar to those observed in different tumor entities. The classification is complex, but is closely relevant to the prognostic and therapeutic aspects. Although hematoxylin-eosin staining is still the gold standard method used for the diagnosis, immunohistochemistry (IHC) can enhance the accuracy and be a helpful tool when in cases to investigate the subjects that cannot be assessed by histological examination, such as the cell nature and differentiation status, cell proliferation, and tumor protein expression. This review depicts on the practical diagnostic utility of IHC in salivary gland tumor pathology under the following issues: assessment of cell differentiation, focusing on neoplastic myoepithelial cells; discrimination of histologically mimic tumor groups; diagnosis of specific tumor types, e.g., pleomorphic adenoma, adenoid cystic carcinoma, and salivary duct carcinoma; and evaluation of malignancy and prognostic factors. IHC plays a limited, even though important, role in the diagnosis of salivary gland tumors, but is often useful to support the histological assessment. However, unfortunately few tumor type-specific markers are still currently available. For these reasons, IHC should be considered a method that can be used to assist the final diagnosis, and its results themselves do not directly indicate a definitive diagnosis.
- 日本組織細胞化学会の論文
著者
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Oshiro Hisashi
Department Of Pathology Tokyo Medical University
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Nagai Takeshi
Department Of Applied Chemistry School Of Science And Engineering Waseda University
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Matsubayashi Jun
Department Of Diagnostic Pathology Tokyo Medical University
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Inoue Rie
Department Of Anatomic Pathology Saiseikai Central Hospital
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Obikane Hiyo
Department Of Pathology School Of Medicine Nihon University
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Sato Eiichi
Department Of Information And Electronics Engineering Niigata Institute Of Technology
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NAGAO Toshitaka
Department of Anatomic Pathology, Tokyo Medical University
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Yoshida Maki
Department of Anatomic Pathology, Tokyo Medical University
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H. Takahashi
Department of Anatomic Pathology, Tokyo Medical University
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Suzuki Fumie
Department of Anatomic Pathology, Tokyo Medical University
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Yamashina Mitsumasa
Department of Anatomic Pathology, Tokyo Medical University
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Inoue Rie
Department of Anatomic Pathology, Tokyo Medical University
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Obikane Hiyo
Department of Anatomic Pathology, Tokyo Medical University
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Oshiro Hisashi
Department of Anatomic Pathology, Tokyo Medical University
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Matsubayashi Jun
Department of Anatomic Pathology, Tokyo Medical University
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