Lignans and Triterpenes from the Root of Pseuderanthemum carruthersii var. atropurpureum
スポンサーリンク
概要
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Two new lignans, pseuderesinol (1), pseuderanoside (2) and a new triterpene, pseuderanic acid (3) were isolated from the dried root of Pseuderanthemum carruthersii (SEEM.) GUILL. var. atropurpureum (BULL.) FOSB. (Acanthaceae), together with ten known compounds, including five lignans, (+)-eudesmin (4), (+)-magnolin (5), (+)-syringaresinol (6), (+)-episyringaresinol (7), (+)-1-hydroxysyringaresinol (8) and five triterpenes, squalene (9), oleanolic acid (10), lupeol (11), betulin (12), betulinic acid (13). Their chemical structures were elucidated by 1D- and 2D-NMR, computational quantum chemistry, as well as high resolution-electrospray ionization (HR-ESI)-MS spectroscopic analysis. The acetylcholinesterase inhibition and cytotoxic activities against HeLa and MCF-7 cancer cell lines were evaluated on some purified compounds at the concentration of 100 µg/mL. Pseuderesinol (1) and magnolin (5) exhibited moderate cytotoxic activities against the MCF-7 cancer cell line.
著者
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Pratt Lawrence
Department Of Chemistry Fisk University
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Nguyen Ngoc
Department of Chemistry, University of Science, National University–Ho Chi Minh City
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Tuong Lam
Department of Chemistry, University of Science, National University–Ho Chi Minh City
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Vo Thi
Department of Chemical-Food Technology, University of Technical Education–Ho Chi Minh City
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Nguyen Phi
Department of Chemistry, University of Science, National University–Ho Chi Minh City
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Vo Phung
Department of Pharmacy, University of Medicine and Pharmacy
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Nguyen Kim
Department of Chemistry, University of Science, National University–Ho Chi Minh City
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Nguyen Kim
Department of Chemistry, University of Science, National University–Ho Chi Minh City
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Nguyen Phi
Department of Chemistry, University of Science, National University–Ho Chi Minh City
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Pratt Lawrence
Department of Life and Physical Sciences, Fisk University
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Vo Thi
Department of Chemical-Food Technology, University of Technical Education–Ho Chi Minh City
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