New Rotenoids and Coumaronochromonoids from the Aerial Part of Boerhaavia erecta
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概要
- 論文の詳細を見る
From the aerial part of Boerhaavia erecta L., three new rotenoids (3, 8, 10) and two new coumaronochromonoids (6, 11) were isolated, together with ten known compounds. The structure of the new compounds was established by one dimensional (1D)- and 2D-NMR spectroscopy, as well as high resolution-electrospray ionization (HR-ESI)-MS analysis. The absolute configuration of compound 11 was determined by UV circular dichroism spectroscopy. Compounds were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 µg/mL. Rotenoids 3, 4 and 5 showed a strong cytotoxic activity against HeLa cell line and rotenoids 5 and 8 showed good activity against MCF-7 cell line.
著者
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Pratt Lawrence
Department Of Chemistry Fisk University
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Watarai Hitoshi
Institute For Nanoscience Design Osaka University
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Yamamoto Shigeki
Department Of Chemistry Graduate School Of Science Osaka University
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Nguyen Kim
Department of Chemistry, University of Science, National University–Ho Chi Minh City
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Truong Anh
Department of Organic Chemistry, University of Science, National University–Ho Chi Minh City
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Do Thi
Department of Organic Chemistry, University of Science, National University–Ho Chi Minh City
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Pinnock Travis
Department of Physical, Environmental and Computer Sciences, Medgar Evers College, The City University of New York
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Pratt Lawrence
Department of Physical, Environmental and Computer Sciences, Medgar Evers College, The City University of New York
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Guillaume Dominique
School of Pharmacy
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