実験的慢性腎不全における高血圧の発生要因についての考察

概要

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Resection of a unilateral kidney with contralateral nephrectomy was performed to induce chronic renal failure in a group of rats. In another group, one third of the kidney was resected to increase the remaining renal parenchyma compared with the previous group, and 1 % saline solution was added to drinking water as a means of administration. The changes in blood pressure, serum urea nitrogen, plasma renin activity and histological findings on the remaining kidney were studied in order to clarify the mechanism of hypertension in chronic renal failure. The results showed that a similar blood pressure elevation to that obtained in chronic renal failure can, to a certain extent, be induced by reducing the renal mass. It was also shown that a marked rise in blood pressure and severe renal lesions, compared with the rise in urea nitrogen, occurred after administraton of saline solution in the later group. Plasma renin activity fell in proporton to the remaining renal mass and decreased further after administration of saline in this model. The extent of renal lesion, along with the volume load, may have affected elevation of blood pressure in this model of chronic renal failure.
学校法人昭和大学・昭和医学会の論文