小児アレルギ-疾患におけるスクラッチテストとRASTに関する研究

概要

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The results of RAST to mite, silk, egg white, shrimp and buckwheat allergen were compared with those of clinical allergy diagnosis by scratch tests, case history and serum IgE levels. Seventy children were selected because of suffering from atopic allergy to more than one substance, resulting in bronchial asthma and other symptoms. In this study, RAST was performed using batches of allergen perticle complex and 125I-labbeled anti-IgE as in the study reported by Wide et al. APC were prepared in the method described by Ceska et al. An over-all correlation between scratch tests and RAST was established in 76.2 per cent. Result of RAST showed higher correlation with scratch tests to inheller antigens. In any antigen, serum IgE levels were not correlated with RAST counts. Clinical history of food hypersensitivities was well correlated with positive RAST. Finally, significantly positive correlation of result of carefully performed skin tests with RAST values suggests the possibility that the RAST can be employed as reliable diagnostic aid.