小児気管支喘息に於けるテオフィリン投与法に関する研究-1-アミノフィリン静注および点滴静注における血清テオフィリン濃度について

概要

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Intravenous administration of aminophylline was studied in 20 asthmatic children. The serum concentration of theophylline in oneday was measured in the definite time intervals. A safe and effective dosage regimen for intravenous aminophylline administration can be based on these clinical observations. The serum concentrations of theophylline were measured by homogeneous enzyme multiplied technique (EMIT) . At the same time, EMIT was correlated with High-Pressure Liquid Chromatography (HPLC) in 39 patients' samples (r=0.980) and Gas Chromatography (GC) in 18 patients' samples (r=0.961) . In the group receiving a constant infusion of aminophylline (21 mg/kg/day), the serum theophylline level rose very slowly and was markedly low in the first stage of infusion. The initial infusion of 6 mg/kg, as a loading dose, was followed by the maintenance dose of 18 mg/kg/day. In this group, serum theophylline concentration was constantly maintained at the higher level of 10 to 14μg/ml by this method, and an immediate clinical improvement with increase in the PFR was observed. In conclusion, to obtain the ideal therapeutic range of theophylline level, we suggest that the initial infusion of 5 or 6 mg/kg over 5 min should be followed by 18 mg/kg/day, as a maintenance dose.
学校法人昭和大学・昭和医学会の論文