家兎大腿四頭筋が注射及びギプス固定によつて起る影響について--筋の引張破断試験ならびに組織学的検討

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概要

• 論文の詳細を見る

• In young rabbits (500-600 g) receiving 3 consecutive daily injections of chloramphenicol (CP) into the quadriceps muscle or reard under immobilization of the hind leg with a cast the tension and histologic changes of the quadriceps muscle were examined in course of time with the following results:<BR>1. Relatively localized fibrosis and the presence of excessive fat cell were found in the quadriceps muscle injected with CP.<BR>2. Marked atrophy of musculature occurred in the quadriceps muscles of the rabbits with an immobilized hind leg with a cast. The longer the duration of cast immobilization was, the stronger this changes was.<BR>3. The rectus femoris muscle was found in the tensile-breaking test to rupture at the muscle-tendon region approximately 10 cm proximal to the patella.<BR>4. The stress-strain diagram at rupture of the rectus f emoris muscle gave value varying from 2.0 to 3.0 cm. When reached 25 to 30% of the whole length of the muscle, it developed complete rupture.<BR>5. Tension of the rectus femoris muscle reached a peak after 8 weeks when fibrosis and the presence of excessive fat cell were marked. It was also the strongest in the strongest in the animals subjected to 8 weeks' cast immobilization, in which atrophy and fibrosis of musculature were histologically confirmed.<BR>6. The present study suggested the relation between fibrosis, atrophy, fatty degeneration, etc. of musculature and the development of muscular contracture. Accordingly, it will be desirable to avoid such a treatment as causing fibrosis of musculature as far as possible for prevention of muscular contracture.

• 学校法人 昭和大学・昭和医学会の論文

著者

• 三上 洋三

  昭和大学医学部大学院医学研究科外科系整形外科学

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