Ceruloplasminに関する研究特に,その造血作用の検討

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Serum iron, copper, transf errin and ceruloplasmin level were measured in rabbits receiving repeated injection of reduced ceruloplasmin and urinary erythropoietin isolated from patients of hypoplastic anemia, checking the number of erythrocytes, reticulocytes, hemoglobin level and bone marrow picture. These were compared with the rabbits placed under low atmospheric pressure. The results obtained were as follows. 1) The serum iron level was lowered within one week, in all experimental groups of rabbits administered ceruloplasmin, apoceruloplasmin and urinary erythropoietin and of rabbits in hypoxic hypoxia. 2) The serum copper and ceruloplasmin value decreased in rabbits administered urinary erythropoietin and placed under hypoxic hypoxia, while it increased in the groups administered urinary erythropoietin and placed under hypoxic hypoxia, while it ceruloplasmin and apoceruloplasmin. 3) Reticulocytosis in peripheral blood and marked hyperplasia of bone marrow were observed in all experimental groups. 4) Serum total and unsaturated iron binding capacity increased markelly in all groups. 5) Plasma of rabbits receiving repeated injection of ceruloplasmin accelerated Fe59 incorporation into peripheral erythrocytes of rats. It is assumed that reduced ceruloplasmin has an erythropoietic activity as urinary ethropoietin.
昭和大学・昭和医学会の論文