家兎のVitamin B1代謝に及ぼすNicotineの影響について
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概要
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Rabbits administered of nicotine either by a single injection of 10 mg/kg or by a daily dose of 1 mg/kg repeated for 10 days were determined of the total quantity of vitamin B<SUB>1</SUB> as well as its blood and urine concentration. In either case of the two kinds of nicotine administration, there was a remarkable decrease of vitamin B<SUB>1</SUB> on the first day after completion of the injection. This tendency was especially strong on those which had received 1 mg/kg repeatedly for 10 days and they also required a longer period in restoring their normal condition.<BR>Moderate degenerative changes were observed on the liver and the kidney of the rabbits received a daily dose of 1 mg/kg nicotine for 10 days.
- 学校法人 昭和大学・昭和医学会の論文
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