OXYMETHYLPYRIMIDINEの薬理 : (III)OXYMETHYLPYRIMIDINE, ビタミンB_1ならびにニコチン急性中毒と2,3薬物の痙攣抑制効果について

概要

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Oxymethylpyrimidene (OMP) causes acute toxic symptoms such as clonic and tonic convulsions in the animal, though there is a slight difference among monkey, dog, cat, rabbit, mouse and chicken. But OMP does not induce a paralysis which occurs in the case with thiamine and nicotine. The convulsion induced in animals by the administration of these drugs is frequently interrupted by short intervals, and the paroxym is prolonged as the time elapsed. The toxic dose of OMP for man, calculated from that for monkey, is 1.0〜1.5g/50 kg. The OMP-convulsion is inhibited by pyridoxine even after the administration of OMP, while the antagonism by β-hydroxy-γ-aminobutyric acid, thiamine or ascorbic acid is incomplete. The thiamine-convulsion cannot be suppressed by any of these drugs employed. To the nicotine-convulsion, thiamine and ascorbic acid exert an antispasmodic action to some extent.