成熟婦人における増殖期子宮内膜の細胞学的検討--分岐腺管出現の意義

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The present study investigated the endometrial cytology in the proliferative phase of normal menstrual females. Materials for endometrial cytology were obtained from 156 females diagnosed with negative cytology. Cytological examination investigated the following variables: 1) the structure of the gland, 2) the nuclear area and the roundness of the endometrial gland cell, 3) the nuclear area and the roundness of the endometrial stromal cell, and 4) the configuration of the vessel. In addition, if present, for the branching duct-like structure, the same examination was performed. Furthermore, 8 cases of endometrial tissues were used to observe the three-dimensional structure of endometrial glands. Cytological findings of the proliferative phase endometrium were consistent with those reported in the previous literature: the endometrial glands had mainly straight tubules. In addition, branching glands were observed in 14.1% of the total material, which were either two-branching (95.4%) or three-branching (4.6%) . Maximally 8 branching glands, minimally 1, and 3.0 on average were observed in every case. The branching gland to total endometrial gland ratio was proportionate in incidence in the early-, mid-, and late-proliferative phases, showing an average of 2.9%, indicating that the branching glands began branching and extending in the very early stage of proliferation. In addition, three- dimensional structure showed that branching glands occurred at a rate of 25.0%. This study confirmed branching glands, which had been considered to be one kind of evidence in endometrial hyperplasia, in the normal proliferative phase endometrium. Therefore, this recognition is necessary for future cytoscreening of branching glands that may be present in the proliferative phase endometrium in normal females.
学校法人昭和大学・昭和医学会の論文

成熟婦人における増殖期子宮内膜の細胞学的検討--分岐腺管出現の意義

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