前立腺癌細胞に対する大豆イソフラボン(Genistein,Daidzein,Equol)のアンドロゲンレセプター発現抑制および細胞増殖抑制効果の検討

概要

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Asian people are known to have a lower incidence of prostate cancer compared to the USA and other western countries. This difference has been explained, in part, by soy intake because soybean isoflavones called phytoe-strogens, such as genistein, daidzein and equol (a metabolite of daidzein), are known to have weak estrogenic activity. In the current study, we examined the effects of these soybean isoflavones on regulation of androgen receptor (AR) and proliferation of LNCaP cells, a prostate cancer cell line that grows in an androgendependent manner. Flow cytometric analysis showed that AR was down-regulated by genistein and equol in a dose-dependent manner, whereas it remained unchanged by daidzein. Consistent with these results, proliferation of LNCaP cells was efficiently inhibited by genistein and equol, but daidzein showed a much weaker effect. These results suggest that genistein and equol inhibit prostate cancer proliferation through down-regulation of AR.
学校法人昭和大学・昭和医学会の論文