ブドウ糖非醗酵性グラム陰性桿菌による慢性化膿性中耳炎に関する知見

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I report herein sensitivity tests (MICs) to antibiotics and treatment courses of patients with chronic suppurative otitis media due to glucose non-fermentative gram-negative rods isolated and identified in the otorrhea.Isolated six rods of A. xylosoxidans, one rod each of P. maltophilia, Flavobacterium sp. and Alcaligenes, and two rods of A. calcoaceticus showed the lowest MICs to doxycycline, and next to gentamicin, but high MICs to ampicillin and to sulbenicillin.Doxycycline I. V. in one dose was administrated to six patients with identified A. xylosoxidans which were sensitive at the second tests. Here other antibiotics were sensitive to St. aureus isolated and identified in the otorrhea at the initial tests were not effective.More than three minutes were needed to inject 100mg of doxycycline in 20ml of 5% glucose solution (doxycycline dosage: 100mg per day).Doxycycline was effective in three cases (50%), slightly effective in 1 (16.7%) and not effective in 2 (33.3%).No side effects were observed during the doxycycline I. V. therapy.
耳鼻咽喉科臨床学会の論文