耳鼻咽喉科領域におけるCeftizoximeに関する基礎的ならびに臨床的研究
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Fundamental and clinical investigations with Ceftizoxime, a new cephalosporin derivative, were performed with the results which might lead to the following conclusion:1) In vitro antibacterial activity: The minimum inhibitory concentration of Ceftizoxime was tested by an agar plate dilution method. Ceftizoxime results in excellent, broad spectrum antibacterial activity against standard strains of various bacteria. Ceftizoxime had same antibacterial spectrum like those of other cephalosporin antibiotics. The MIC of Staphylococcus aureus isolated from otorrhea was distributed at a range from 0.39 to 50μg/ml of Ceftizoxime, showing its peak at 3.13μg/ml. Other strains of Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae were inhibited by ≤0.2 to 3.13μg/ml of Ceftizoxime. Ceftizoxime showed the MICs of 3.13 to ≥100μg/ml, its peak at 25μg/ml against 60 strains of pathogenic Pseudomonas aeruginosa.2) Concentration in serum: The serum level of Ceftizoxime in healthy adults given 500mg reached a maximum of 32.9μg/ml at 15 minutes after intravenous injection. Even 6 hours after intravenous injection, clinically effective serum Ceftizoxime concentration 0.7μg/ml was still demonstrable.3) Concentration in tissues: Activity of Ceftizoxime was demonstrable at the concentration of 3.0μg/g in human palatine tonsilla and 2.5μg/g in mucous membrane of maxillary sinus one hour after intravenous injection, when the serum concentration of Ceftizoxime was 14.5 and 14.8ug/ml, respectively.4) Results of clinically treatment: When Ceftizoxime was intravenously injected to 26 cases of representative infection in the otorhinolaryngologic field, clinical results were excellent in 22 cases good in 3 cases and fair in one case. When the excellent and good cases were considered together, clinical response were obtained in 22 cases, 96.2 per cent.Side effect: No side effect was shown with intravenous injection of Ceftizoxime.
- 耳鼻咽喉科臨床学会の論文
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