アミノベンジルペニシリンの胃腸障害を防止するためのドグマチ-ルの併用効果

概要

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Patients with otorhinolaryngological related infections were treated with 750mg of ABPC given in three divided doses, either alone or with 3 capsules of Dogmatyl, for 4 or more days. The patients were observed for development of gastrointestinal disorders including loss of appetite, nausea, vomiting, gastric distress, heartburn, belching, loose stool, and sensation of fullness in the abdomen.The overall incidence of these disorders was considerably lower in patients who were concomitantly given Dogmatyl (15%, i. e. 8 in 52) than in patients given ABPC alone (27%, i. e. 14 in 52).As for the incidence of loose stool, the difference between the two groups was even greater: 10% (5 in 52) and 21% (11 in 52), respectively.
耳鼻咽喉科臨床学会の論文