Effect of OK-432 on the cumulative survival of patients with tumors of the head and neck.

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In 82 patients with stage II or III malignant tumors of the head and neck, the cumulative survival rate was compared between 55 treated with and 27 not treated with OK-432. The annual survival rate was consistently higher in those treated than in those not treated with the agent; a significant difference was observed after 3 years and a slight different after 5 years.Intracutaneous administration of OK-432 had no effects on the cumulative survival rate, presumably because activation of pyrimidine fluoride compounds was unaffected.Of 57 parameters tested, we describe 9 immunological and biochemical parameters used in our hospital that indicate the onset and prognosis of malignant tumors of the head and neck. These parameters were:aspirin esterase, fibrinogen, a2-globulin, and cholinesterase levels; lymphocyte count, Su-Ps skin test, and PPD skin test; lymphocytes blastgenesis to PHA; and iron level.
耳鼻咽喉科臨床学会の論文