Salivary Duct Carcinoma in the Submandibular Gland; A Report of Two Cases

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Salivary duct carcinoma is an uncommon tumor, and mainly originates in the parotid gland. We treated two patients with salivary duct carcinoma in the submandibular gland. One patient was a 60-year-old male who complained of right submandibular swelling. Submandibular sialoadenectomy, right neck dissection and postoperative radiation were performed. Four months later, multiple bone metastase were found. The other patient was a 40-year-old male who complained of right submandibular and bilateral cervical swelling. Submandibular sialoadenectomy, bilateral neck dissection, and postoperative radiation and chemotherapy were performed. Six months later, skin metastasis was found. Histologically, both were diagnosed as salivary duct carcinoma based on the presence of cribriform pattern and comedo necrosis. Preoperative diagnosis of salivary duct carcinoma is difficult. This carcinoma resists combined therapy and has a poor prognosis.
耳鼻咽喉科臨床学会の論文