内リンパ嚢の病理組織 (メニエ-ル病の研究-3-<特集>)

概要

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Histopathological studies were performed on the endolymphatic sac in serial sections of 69 children and adults (123 ears) and 15 fetuses (30 ears). In the latter (13-39 weeks), the endolymphatic sac showed a wide, single lumen which did not contain precipitates. Rugosity was absent here. In 20% of all the adult endolymphatic sacs, the sac lumen showed a tubular, branched form which was not particularly related to the pathology of the inner ear. The dark pigment in the perisaccular tissue appeared to be melanin. This pigment was found in 44% of 125 ears and was not related to age, sex or inner ear pathology. Nineteen percent of adult ears showed a polypoid hyperplasia. Retention of thick precipitates in the sac lumen was observed in 47% of all ears. These precipitates were identified as mucopolysaccharide and mucoprotein, occupying almost all the lumen of the intermediate portion. No correlation was found between these precipitates in the sac and pathology in the endolymphatic system of inner ear. These pathological findings in the human endolymphatic sac make for a difficult evaluation of the endolymphatic sac, as related to causative factors of endolymphatic hydrops and/or other endolymphatic disorders.
耳鼻咽喉科臨床学会の論文