各種利尿剤とグリセロ-ルによる内耳への影響 (前庭機能異常の研究-2-<特集>)

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In recent years, glycerol or loop diuretic agents are known to be the drugs considered to reduce endolymphatic hydrops, there by it has been used for the diagnosis and partially a therapy for the inner ear dizziness.In this present study, the above agents and generally used various diuretic agents have been administrated to animals experimentally, and those effects against the stria vascularis were observed by electron microscopy.The change in substance-permeability of the stria vascularis by diuretics were reviewed by a tracer using horseradish peroxidase. Subsequently, the following results were obtained.1) After intravenous injection of furosemide and bumetanide, temporary reversible change was observed at the stria vascularis.2) By the tracer study, furosemide has an action of easing the leakage of substances to the endolymphatic space.3) By oral administration of furosemide, no abnormality was observed.4) Metholazone as a thiazide type diuretic agent in its intravenous injection caused slight changes.5) Intravenous injection of potassium canrenoate as an antialdosterone drug was proved to show the same effect as that of loop diuretic agents.6) Glycerol, mannitol and isosorbide showed no marked change in the inner ear.
耳鼻咽喉科臨床学会の論文