半規管膨大部クプラの発生 (前庭機能異常の研究-2-<特集>)

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Development of the cupula in the ampullae was observed by scanning and transmission electron microscopy, using fetus and mature rats. Adult mice crista was also observed.At the 16th day of fetus, Cupula was often observed on the crista, and homogenous substances were found on the supporting cells of crista. At the 17th day of fetus, the similar substances buldged on the supporting cells and connected with the marginal processus of the cupula. Therefore, it is strongly suggested that the cupula possibly originated from the supporting cells on the crista at the 16th day of fetus in rats. At the 19th day of fetus, the cupula was almost completely formed. Immediately after birth, morphological findings such as thickness, extension, surface structure of the cupula and subcupular space were almost complete. On the other hand, TEM examinations revealed that vestiform structure of the cupula first appeared at the 19th day of fetus, while mesh or fibrous structure was observed in the cupula on as early as the 17th day of fetus.
耳鼻咽喉科臨床学会の論文