Comparison of CAP-FEIA and RAST in the Diagnosis on Nasal Allergy.

概要

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The value of the radio allergosorbent test (RAST) in the detection of specific IgE antibody has been investigated by many researches.However, the clinical usefullness of the CAP-fluoro enzyme immuno assay (CAP-FEIA) method recently introduced for the same purpose as the RAST method is still not clear. The authors used both the RAST and the CAP-FEIA methods to test the same patients with nasal allergy and compared the results.It was found that the CAP-FEIA method was more sensitive than the RAST method in the detection of specific IgE antibodies to single or multiple antigens in patients with nasal allergy, except for house dust antigens. Further investigation showed that the lower sensitivity to house dust antigen was due to the impurities in the house dust extract.Reexamination with a new standard house dust extract showed as high sensitivity as to the other antigens. The CAP-FEIA method showed a better correlation with the results of skin tests than did the RAST method.It is concluded that CAP-FEIA is an excellent method for the diagnosis of nasal allergy.