Changes of 5-FU concentration in the tissue and serum of patients with maxillary cancer treated with UFT.

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概要

• 論文の詳細を見る

• 5-FU and FT-207 concentrations in serum and tumor tissues of four patients with maxillary cancers were measured after treatment with UFT.1. Initial concentrations of 5-FU in tumor tissues after the administration of UFT (600mg 3 days) were at least 0.05mcg/g, a satisfactory level.2. Levels of FT-207 in tumor tissue were consistently lower than in the serum, while levels of 5-FU in tumors were about 2-5 times higher than in the serum.3. 5-FU concentrations in three patients continued to be more than. 0.05mcg/g at 8 hours and were highest at 1 4 hours, indicating that a dose of 600mg/day of UFT maintained effective concentrations.When combined with radiation therapy and local necrotomy, UFT appears to be an effective anticancer agent for maxillary cancer.

• 耳鼻咽喉科臨床学会の論文

著者

• 田坂 康之

  京都大学医学部耳鼻咽喉科学教室

• 大村 正樹

  神戸中央市民病院耳鼻咽喉科

• 玉城 進

  同仁病院耳鼻咽喉科

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