The effect of a single antral lavage with and without pipemidic acid on chronic sinusitis.

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This study was designed to determine the effectiveness of a single antral lavage with and without pipemidic acid (PPA), an oral antibacterial agent, in chronic sinusitis. Fifteen patients, aged 17 to 66 years, were treated with an antral lavage with physiological saline solution at week one (group A). Thirteen patients, aged 14 to 68 years, were treated with an antral lavage at week one and recieved PPA 2, 000mg p. o. per day for two weeks, from week 0 to week 2 (group B).There was no significant difference in the subjective effect between group A and group B. X-ray opacity of the maxillary sinus was evaluated with a microdensitometer at week 0 and week 2. In group A, the x-ray opacity was 0.597±0.166 at week 0., and was 0.595±0.174 at week 2. In group B, the x-ray opacity was 0.665±0.190 and 0.683±0.176 at weeks 0 and 2, respectively. No significant improvement of x-ray opacity was observed after treatment in either group.The results indicate that a single antral lavage with and without an antibacterial agent is ineffective on the conservative treatment of chronic sinusitis.
耳鼻咽喉科臨床学会の論文