慢性副鼻腔炎に対する蛋白分解酵素セアプロ-ゼS(キョ-リナ-ゼ錠)の治療効果

概要

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In this report the effect of Seaprose-S on chronic paranasal sinuitis has been studied. Fours Kyorinase tablets (each containing 10mg of Seaprose-S) were administered daily at four equal doses to 24 patients older than 15 years with chronic paranasal sinusitis, and the efficacy was evaluated after 2 or 4 weeks of administration.The subjective symptoms evaluated were rhinorrhea, postnasal drip, nasal obstruction, head heaviness and sense of smell, and the objective signs evaluated were reddening, edema on the nasal mucosa and amounts and properties of nasal secretion. Radiographic diagnosis was also carried out before and after treatment.The global utility rate of Kyorinase based on the clinical efficacy and safety was about 60%. Neither adverse effects nor abnormal laboratory findings with respect to hepatic functions or renal functions were observed in any of the cases.
耳鼻咽喉科臨床学会の論文