ラットの急性内耳障害とうつ傾向の関係

概要

論文の詳細を見る
Depression is a known cause of dizziness; conversely, there is no clear evidence that dizziness is a cause of depression or a depressive state. We developed a model of inner ear impairment by infusing 30 μl of cisplatin solution (0.5 mg/ml cisplatin in phygiolosical saline) into the middle ear cavity of a rat. Starting on the following day, the rat turned its neck and trunk to the side of the infusion and did not exhibit auditory brainstem response. This model of dizziness was then used in the following experiments. Plasma corticosterone and immobility time in a forced swimming test were measured 3 days, 7 days, 4 weeks, and 8 weeks after the infusion of cisplatin. In this model of dizziness, arise in plasma corticosterone levels was seen at 3 and 7 days after infusion. Immobility time in the forced swimming test was also increased at 3 days. Administration of the anxiolytic diazepam resulted in a decrease in plasma corticosterone in this model of dizziness. The above findings demonstrate that dizziness can be a cause of a depressive state. This suggests that in treating dizziness it is necessary to treat not only the dizziness itself but also to conduct psychotherapy or to administer antianxiety agents in certain cases.
愛知医科大学の論文
2003-12-15