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The development of the rabbit olfactory bulb was studied by electron microscope. Olfactory bulbs were obtained from rabbit fetuses 18-28 days before birth and three days after birth. The left ventricles of the fetuses were perfused with 3% glutaraldehyde in phosphate buffer, and the 3-day-old rabbits were injected with the same solution into the ascending aorta under nembutal anesthesia. The olfactory bulbs were extirpated, post-fixed in 1% osmium tetroxide, dehydrated in graded ethyl alcohol, and embedded in the routine way in Epon 812. Sagittal ultrathin sections were stained with uranyl acetate and lead citrate.1) The differentiation of the neuron in the olfactory bulb occurred after the axons of olfactory receptor cells in the olfactory epithelium had formed the olfactory nerve layer of the olfactory bulb.2) In the olfactory bulb, the mitral cells differentiated first of all. The tufted cells, the periglomerular cells and the granule cells differentiated subsequently.3) The centripetal connection in the glomerular layer between the olfactory receptor cell and the mitral cell developed in parallel with the differentiation of the mitral cell, and was almost completed by the last fetal stage. Therefore, it is concluded that olfactory function may operate immediately after birth.4) The synaptic formation between the periglomerular cell and the mitral cell or the tufted cell, the mitral cell and the granule cell, and the granule cell and the bulbopetal fibers from the central nervous system, was still incomplete even on the 3 days after birth. These facts suggest that the inhibitory synaptic connection is completed by the stimulus of olfaction during postnatal development.
- 耳鼻咽喉科臨床学会の論文