正円窓膜の酸素透過性に関する研究-3-長期正円窓膜閉鎖後の内耳機能及び外リンパ酸素分圧

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After closure of the round window membrane of guinea pigs by various adhesive agents (histoacryl, alonalfa and dental cement), inner ear function was observed by cochlear microphonics (CM) and action potential (AP). At the same time, perilymphatic oxygen tension in the scala tympani was measured by polarographic methods.In addition to these chronic experiments, dynamic changes of the perilymphatic oxygen tension were measured during the flow of air, pure oxygen and nitrogen under general anesthesia.1) CM and AP fell significantly after three weeks, but did not change just after or three days after closure of the round window membrane.2) The perilymphatic oxygen tension increased significantly after a flow of pure oxygen, but decreased after nitrogen.3) The perilymphatic oxygen tension of the closed side three weeks after closure of the round window membrane decreased to about 50% that of the non-closed side.We assume that these results were caused by the decrease of oxygen supply caused by closure of the round window membrane.
耳鼻咽喉科臨床学会の論文