THE ACTION OF 2-METHYL-4-AMINO-5-AMINO-METHYLPYRIMIDINE
スポンサーリンク
概要
- 論文の詳細を見る
1. 2-methyl-4-amino-5-aminomethylpyrimidine inhibits brain glutamic decarboxylase. It also has an inhibitory effect on bacterial tyrosine decarboxylase.2. The restoration of the glutamic decarboxylase inhibition by PAL phosphate differs according to whether the 2-methyl-4-amino-5-aminomethylpyrimidine comes in contact with the enzyme before or simultaneously with the substrate. Restoration takes place in the case of the latter but not in the former.3. An inhibitory effect is also observed against brain ABA-KGA transaminase but there is no difference whether the contact is before or simultaneous.4. This inhibition is overcome by PAL phosphate.5. 2-methyl-4-amino-5-aminomethylpyrimidine inhibits brain PAL kinase. An apparent enhancement of activity was observed, however, in the case of PAL kinase purified from brewer's yeast.
- 日本ビタミン学会の論文
著者
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KODAMA TEISUKE
Department of Pediatrics, Faculty of Medicine, Osaka University
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NISHIZAWA YOSHITO
Department of Pediatrics, Faculty of Medicine, Osaka University
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MORIYA TOSHIRO
Department of Pediatrics, Faculty of Medicine, Osaka University
関連論文
- THE SUPPRESSIVE EFFECT OF γ-AMINOBUTYRIC ACID AND β-HYDROXY-γ-AMINOBUTYRIC ACID ON THE RUNNING FIT
- THE RUNNING FIT-INCITING ACTION OF CARBONYL REAGENTS
- GLUTAMYLCHOLINE IN THE TREATMENT OF HYPERTENSION
- THE ACTION OF 2-METHYL-4-AMINO-5-AMINO-METHYLPYRIMIDINE
- THE TOXOPYRIMIDINE GROUP SUBSTANCES
- EFFECT OF HYDROXYMETHYLPYRIMIDINE ON BRAIN TRANSAMINASE AND GLUTAMIC DECARBOXYLASE
- ATOXOPYRIMIDINE GROUP SUBSTANCES
- INHIBITION OF BRAIN GLUTAMIC DECARBOXYLASE BY RUNNING FIT-INDUCING SUBSTANCES
- GLUTAMIC DECARBOXYLASE AND γ-AMINOBUTYRIC-α-KETOGLUTARIC TRANSAMINASE ACTIVITIES DURING AND ON SUPRESSION OF THE RUNNING FIT
- BRAIN γ-AMINOBUTYRIC-α-KETOGLUTARIC TRANSAMINASE
- BRAIN γ-AMINOBUTYRIC ACID DURING AND ON SUPPRESSION OF THE RUNNING FIT
- HISTOLOGICAL INVESTIGATIONS ON THE LIVER-DISTURBING ACTION OF 2-METHYL-4-AMINO-5-HYDROXYMETHYLPYRIMIDINE