THE TOXOPYRIMIDINE GROUP SUBSTANCES

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概要

• 論文の詳細を見る

• 1. The antagonistic relationship between OMP and vitamin B6 was studied using the running fit as an index. Pyridoxine (PIN) was found to have a suppressive effect when less than 1500μg/g of OMP was used. When the dose of OMP is raised to this limit, an almost equal quantity of vitamin B6 is required for suppression.2. Two additional compounds, similar in structure to OMP, were also found to induce running fits.3. The toxicity of these compounds is lower than that of OMP but the running fit appears earlier.4. Of the two compounds, the running fit induced by 2, 5-dimethyl-4-aminopyrimidine (I) can be suppressed by PIN, but PIN has no effect on the seizure induced by 2, 6-dimethyl-4-aminopyrimidine (II).5. Both I and II are shown to intensify the toxicity of OMP. 2-Methyl-4-aminopyrimidine (III) which singly possesses no toxicity, also intensifies the toxicity of OMP.6. OMP, I, II and III should be called "toxopyrimidine group substances" considering its properties.

• 日本ビタミン学会の論文

著者

• KODAMA TEISUKE

  Department of Pediatrics, Faculty of Medicine, Osaka University

• NISHIZAWA YOSHITO

  Department of Pediatrics, Faculty of Medicine, Osaka University

• MIYAKE MASATOMO

  Department of Pediatrics, Faculty of Medicine, Osaka University

関連論文

• THE SUPPRESSIVE EFFECT OF γ-AMINOBUTYRIC ACID AND β-HYDROXY-γ-AMINOBUTYRIC ACID ON THE RUNNING FIT
• THE RUNNING FIT-INCITING ACTION OF CARBONYL REAGENTS
• GLUTAMYLCHOLINE IN THE TREATMENT OF HYPERTENSION
• THE ACTION OF 2-METHYL-4-AMINO-5-AMINO-METHYLPYRIMIDINE
• THE TOXOPYRIMIDINE GROUP SUBSTANCES
• EFFECT OF HYDROXYMETHYLPYRIMIDINE ON BRAIN TRANSAMINASE AND GLUTAMIC DECARBOXYLASE
• ATOXOPYRIMIDINE GROUP SUBSTANCES
• INHIBITION OF BRAIN GLUTAMIC DECARBOXYLASE BY RUNNING FIT-INDUCING SUBSTANCES
• GLUTAMIC DECARBOXYLASE AND γ-AMINOBUTYRIC-α-KETOGLUTARIC TRANSAMINASE ACTIVITIES DURING AND ON SUPRESSION OF THE RUNNING FIT
• BRAIN γ-AMINOBUTYRIC-α-KETOGLUTARIC TRANSAMINASE
• BRAIN γ-AMINOBUTYRIC ACID DURING AND ON SUPPRESSION OF THE RUNNING FIT
• HISTOLOGICAL INVESTIGATIONS ON THE LIVER-DISTURBING ACTION OF 2-METHYL-4-AMINO-5-HYDROXYMETHYLPYRIMIDINE

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