Metabolic Fate and Mechanism of Action of Chloroethylthiamine:IV. Urinary Metabolites of 35S-Chloroethylthiamine in Chicks
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概要
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The chick urinary metabolites of chloroethylthiamine, a potent coccidiostat, were studied. After 20mg of 35S-chloroethylthiamine was administered to chicks, 17 radioactive metabolites were separated by Amberlite CG-50 column chromatography followed by cellulose thin layer chromatography. Five major metabolites were identified to be unchanged chloroethylthiamine, thiamine, thiamine anhydride, thiamine anhydride sulfoxide and thiamine anhydride sulfone. The amounts were 34.2, 3.3, 18.3, 4.9 and 4.1% of the total urinary radioactivity, respectively. After intraperitoneal administration of 35S-chloroethylthiamine, however, the formation of thiamine was negligible. These results suggest that the gastrointestinal tissue or the intestinal flora might play an important role in the biotransformation of chloroethylthiamine to thiamine. It was indicated that the stimulative effect of chloroethylthiamine on chick growth is due to the formation of thiamine.
- 日本ビタミン学会の論文
著者
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南部 公彦
Central Research Laboratories, Sankyo Co., Ltd.
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駒井 亨
Central Research Labolatories, Sankyo Go., Ltd.
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進藤 英世
Central Research Labolatories, Sankyo Go., Ltd.
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