Chronic Toxicity and Teratogenic Effect of Homopantothenic Acid

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概要

• 論文の詳細を見る

• The safety of HOPA was evaluated by chronic toxicity and teratogenicity tests and the following results were obtained. 1. HOPA was given orally in a dose of 1 and 2g/kg for 6 months in rats in the chronic toxicity test and no significant difference was noted in the weight gain, feed intake, dissection findings, weight of the organs and histological changes as compared with the control. 2. In the teratological test, 1 and 2g/kg of HOPA was given orally to pregnant rats and mice, respectively, every day from the 7th to 14th day of gestation. No effect attributable to HOPA was found in either the foetus or the newborn.

• 日本ビタミン学会の論文

著者

• 甲和 良夫

  Products Control Laboratory, Tanabe Seiyaku Co., Ltd.

• 西沢 義人

  Osaka University

• 堀 正樹

  Products Control Laboratory Tanabe Seiyaku Co., Ltd.

• 野口 祐三

  Products Control Laboratory Tanabe Seiyaku Co., Ltd.

• 中山 良夫

  Products Control Laboratory Tanabe Seiyaku Co., Ltd.

• 児玉 貞介

  Department of Pediatrics, Wakayama Medical College

• 甲和 良夫

  Products Control Laboratory Tanabe Seiyaku Co., Ltd.

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• Chronic Toxicity and Teratogenic Effect of Homopantothenic Acid
• The Antagonistic Action of Homopantothenic Acid against Pantothenic Acid
• Electrophysiological Investigations of Homopantothenic Acid
• Uptake of Homopantothenic Acid by Rat Brain
• COLORIMETRIC DETERMINATION AND PHYSICOCHEMICAL PROPERTIES OF HOMOPANTOTHENIC ACID
• Effect of γ-Aminobutyric Acid Derivatives, Especially, Homopantothenic Acid, on Excitability of the Brain

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