Electrophysiological Investigations of Homopantothenic Acid

概要

論文の詳細を見る
The action of homopantothenic acid (HOPA) on the central nervous system was investigated on the basis of its effect on the transcallosal potential in the cat and spontaneous electroencephalogram in the rabbit. The antagonistic action against pentylenetetrazol- and picrotoxin-induced seizures was also examined electroencephalographically. The following results were obtained.1. Intraarterial injection (carotid artery) and topical application on cortex of HOPA did not affect the transcallosal potential. 2. A slight alert pattern was obtained on the spontaneous electroencephalogram of the unanesthetized restrained rabbit with intravenous injection of 500mg/kg or intracysternal injection of 5mg/kg of HOPA. 3. An antagonistic effect against the electroencephalograms of pentylenetetrazol- and picrotoxin-induced seizures was not observed after intravenous injection of 500mg/kg of HOPA. These electroencephalograms were suppressed by the intracysternal injection of 5mg/kg of HOPA-Na, but complete disappearance of spike-and-wave discharges was not obtained.
日本ビタミン学会の論文