Serum transfer of collagen arthritis to cyclosporin-treated, type II collagen tolerant rats.

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概要

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• The present experiments were aimed to investigate the pathogenesis of collagen arthritis more fully using the passive transfer system.In this work, we intended to dissect some of the immunopathologic reactions by producing collagen arthritis by passive transfer of a serum concentrate from immurized donors to the rats in that antigen-specific suppression was achieved by pharmacologic manipulation. We provide evidence that collagen arthritis can be passively transferred with a serum concentrate to immunologically naive recipients as well as Cyclosporin-treated, type II collagen tolerant rats. In addition, significant enhancement and a longer duration of the passively tmansferred arthritis are induced if cyclosporin is being given continuously. The results of the present experiments indicate that collagen arthritis can be inducible by humoral immunity alone.The results also suggest that a cellular suppressor system, sensitive to cyclosporin, might participate in the regulation of arthritis, once initiated.

• 西日本整形・災害外科学会の論文

著者

• 有田 親史

  浜の町病院整形外科

• 佛淵 孝夫

  九州大学 整形外科

• 森永 政博

  総合せき損センター整形外科

• 高岸 憲二

  九州大学 整形外科

• 貝原 信紘

  九州大学 整形外科

• 有田 親史

  浜の町病院 整形外科

• 森永 政博

  総合せき損センタ ー整形外科

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