Report of four cases of multiple myeloma with low back pain.

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We experienced 4 cases of multiple myeloma with low back pain during the last 2 years. Their X-rays showed severe osteoporosis at the spinal column and punched out lesion at their skulls. Their serum and urinary protein were analyzed. M-protein was present in 3 cases' serum and Bence-Jones protein was proved in 2 cases' urine. We diagnosed these cases as multiple myeloma. These cases were treated with cyclophosphamide, prednisolone and calcitonin. We adopted calcitonin for these cases based on the opinion of Bataille et al that calcitonin was of use in multiple myeloma to treat hypercalcemia as initial therapy. In cases that X-ray shows osteoporosis and routine examinations show abnormality (for example, acceleration of ESR, anemia, abnormality of serum protein, abnormality of bone X-ray etc.), further examinations for multiple myeloma should be made.
西日本整形・災害外科学会の論文