The antibotics effect to bacteria adherent to a biomaterial.

概要

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Biomaterials were exposed to tryptic soy broth containing cells of Staphylococcus E-46 with antibiotics (Cefaloridine 100mg). In group 1, the biomaterials and the antibiotics were put into the broth at the same time. In group 2, the biomaterials were put into the broth at an interval of seven hours after the injection of the antibiotics, and in group 3, at an interval of nineteen hours. After twenty-four hours exposure, the biomaterials of each group were removed for count of bacteria on their surface. Many laboratory data have shown that almost all of free bacteria are killed in two hours under the presence of antibiotics. In this experment, however, there was statistically no difference between groups in the numbers of bacteria on biomaterials. This suggests that the special mechanism exists in the growth of the bacteria on biomaterials. Ultrastructural studies, reported previously, have shown that biofilm develops around the bacteria on the surface of a biomaterial. We reported that the resistance to antibiotics might increase with the growth of biofilm surrounding bacteria on a biomaterial. The result of this experiment supports this speculation.
西日本整形・災害外科学会の論文