Osteonecrosis of the femoral head in spontaneously hypertensive rats. Bone morphometry of the proximal femoral metaphysis.:Bone Morphometry of the Proximal Femoral Metaphysis

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To clarify the cause of osteonecrosis in the femoral heads of spontaneously hypertensive rats (SHRs), we observed the growth plate and trabecular bone in the proximal femoral metaphysis, histologically. Bone morphometry was also carried out to measure trabecular bone volume and trabecular thickness.The growth plate in SHRs showed abnormalities such as decreased thickness, discontinuity and clustering of chondrocytes, etc. Bone morphometry disclosed that metaphyseal bone trabeculae in SHRs was significantly hypertrophic in contrast to those of control rats. In addition, 14 femoral heads with osteonecrosis in SHRs had a tendency towards more increased trabecular bone volume and trabecular thickness than those which had no osteonecrosis.It seemed that abnormalities in the growth plate and metaphyseal bone trabeculae plays a part in the occurrence of osteonecrosis of the femoral heads of SHRs.
西日本整形・災害外科学会の論文