Carcinogenicity Testing of Food Red No. 106(Acid Red) in Fischer 344 Rats.
スポンサーリンク
概要
- 論文の詳細を見る
Male and female Fischer 344/DuCrj rats were treated with Food Red No. 106 (acid red) mixed in the basal diet at doses of 5.0% and 2.5% by weight in a two year toxicity/carcinogenicity study. The mean cumulative intake of Red 106 over the 106 experimental week duration was computed to be 738g/rat and 356g/rat for males at the 5.0 and 2.5% levels, respectively, while females consumed an average of 523 and 252g/animal in the high and low dose group, respectively. Body and organ weights, hematology, urinalysis, and histopathological evaluations revealed no evidence of adverse effects associated with the compound relative to the untreated controls. The spectrum, incidence, and histology of tumors developing in both treated and control animals were consistent with spontaneous incidences reported in this strain of rat. This study thus indicates that Red 106 is not carcinogenic to F344 rats after 2 years of dietary administration at a maximal level of 5.0% in the basal diet by weight.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
- Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey
- Latent Infection of Canine Herpes Virus in Laboratory Beagle Dogs
- Age-specific and Dose-dependent Retinal Dysplasia and Degeneration Induced by a Single Intraperitoneal Administration of N-Methyl-N-nitrosourea to Rats
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points