Organ-specific carcinogenicity of N-methyl-N-nitrosourethane in rats.
スポンサーリンク
概要
- 論文の詳細を見る
Female ACI and Donryu rats were given 40, 20 or 10ppm solutions of N-methyl-N-nitrosourethane (MNUR) continuously in the drinking water. The resulting incidences of tumors were nearly 100% in all groups, animals of both strains showing dose-dependent mean survival times. In both strains of rats, the main target organs were restricted to the upper digestive tract and no strain differences between ACI and Donryu rats were found. Upper digestive tract tumors were found most frequently in the forestomach, followed by the esophagus and oral cavity and/or pharynx. Histologically, they were all squamous cell papillomas or carcinomas. The organotropism of MNUR is compared with those of other N-alkyl-N-nitrosourethanes and also N-alkyl-N-nitrosoureas which have chemical structures analogous to N-alkyl-N-nitrosourethanes.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
- Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey
- Latent Infection of Canine Herpes Virus in Laboratory Beagle Dogs
- Age-specific and Dose-dependent Retinal Dysplasia and Degeneration Induced by a Single Intraperitoneal Administration of N-Methyl-N-nitrosourea to Rats
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points