Relation between albumin-positive hepatocytes and glutathione-S-transferase-positive foci in Nagase analbuminemic rats treated with 3'-methyl-4-diaminoazobenzene.

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Hepatomas were induced in Nagase analbuminemic rats (NARs) by administration of 3'-methyl-4-diaminoazobenzene (3'-Me-DAB), and the correlation between the change in the population of albumin-positive (Alb+) hepatocytes and the area of placental form of glutathione-S-transferase (GST-P) positive foci, an index of preneoplastic foci, was investigated immunohistochemically. The population of Alb+ hepatocytes increased with prolongation in the period of 3'-Me-DAB administration, and this increase was highest in animals without cancer, reaching about twice that in non-cancerous areas of the liver of cancer-bearing animals. This difference occurred because GST-P positive foci contained few Alb+ hepatocytes, which were numerous in non-cancerous areas of the liver in cancer bearing cases. An inverse correlation was also found between the percentage occupancy of GST-P positive foci and the densiry of Alb+ hepatocytes. This inverse relationship between GST-P positive foci and Alb+ hepatocytes was confirmed by studies on partially hepatectomized animals. We inferred from these results that the influence of carcinogens on the albumin gene may be mediated by a different mechanism from that for inducing carcinogenesis.
日本毒性病理学会の論文