Supplementary study of phenylbutazone promoting effects using wide organ spectrum two-stage carcinogenesis models in rats.
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Possible promoting effects of phenylbutazone on carcinogenesis in various organs, including the hematopoietic system and liver, were reinvestigated in inbred female Donryu rats, using wide organ spectrum 2-stage carcinogenesis models. Phenylbutazone was given as a dietary supplement (0.25%) for 24 weeks subsequent to initiation with N-methyl-N-nitrosourea or N-ethyl -N-nitrosourea. No enhancement by phenylbutazone of nitrosourea-induced leukemogenesis was apparent, although a promoting effect was demonstrated, not only for renal and thyroid carcinogenesis as found earlier, but also for hepatocarcinogenesis. On the contrary, an inhibitory effect was shown for intestinal carcinogenesis.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
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