Two case reports of spontaneous gonadal stromal tumors in rats.

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Two testicular tumors classified as so-called gonadal stromal tumor were found in 113-week-old F344 and 103-week-old Slc : Wistar rats. In Case 1 observed in an F344 rat, the cut surface of the testis showed a yellow or yellow-brownish lobular structure. A nodule, surrounded by cells of interstitial cell tumor, demonstrated glandular structure in most areas. The glands were composed of cuboidal cells with eosinophilic cytoplasm and round to oval nuclei with one or two prominent nucleoli. In the marginal area between this lesion and interstitial cell tumor, glandular structure was obscure. In some areas, vacuolated cells with abundant cytoplasm were partially intermingled. In Case 2 in a Wistar rat, a tumor occupied the greater part of the right testis and compressed the surrounding tissue. Histologically, tortuous tubular structures without distinct lumina were formed by elongated or spindle cells in a palisade arrangement on a delicate fibrovascular stroma. Electron microscopically, the tumor cells had a nucleus with irregular invagination. From these findings, it may be considered that Case 1 was a gonadal stromal tumor, although the cell origin was not specified, and that Case 2 was a Sertoli cell tumor.
日本毒性病理学会の論文