Toxic effects of carbon tetrachloride on the primary hepatocyte culture from Mongolian gerbil (Meriones unguiculatus).
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Carbon tetrachloride (CCl4) hepatotoxicity to the primary hepatocyte culture of Mongolian gerbils was studied. Transaminase leakage from cultured cells appeared at 3h-exposure to 0.5 or 1.0mM CCl4 remarkably increasing at 24h. With 0.5mM CCl4, there were marked increase of lipid droplets. aggregation of swollen smooth-surfaced endoplasmic reticulums (sER), dilatation of ER lumen, metamor-phosis of mitochondria, and reduction of periodic acid-Schiff (PAS) reactivity. Cholesterol clefts were produced in ER areas at 3h-exposure, increasing in size and number with time course. These mor-phological changes due to CCl4 were enhanced by previous treating of the culture with phenobarbital.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
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