Five cases of spontaneous hemangioendothelial cell tumor of the heart in B6C3F1 mice.
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概要
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Spontaneous hemangioendothelial cell tumor of the heart was found in five of 4, 160 male and 3, 910 female B6C3F1 (C57BL/6CrSIc×C3H/HeSlc) mice which were used in chronic toxicology and carcinogenicity studies at the An-Pyo Center. Two cases were diagnosed histologically as benign hemangioma and the other three cases were diagnosed as hemangiosarcoma. Hemangioendothelioma of the bone marrow, liver, and spleen were also observed in two out of three cases with hemangiosarcoma of the heart, and these cases were recognized as systemic, multiple vescular cell tumor of B6C3F1 mice. The tumor cells were identified as hemangioendothelial cells by immunohistochemical techniques and lectin binding patterns. The finding of five cases of spontaneous hemangioendothelial cell tumor of the heart in this report is considered to be extremely rare.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
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