Dinitrochlorobenzene(DNCB)-induced delayed-type hypersensitivity reaction in the dorsal skin of hairless dogs.
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Two hairless dogs and 2 Beagles were sensitized by intradermal inoculation of 2, 4-dinitroch-lorobenzene (DNCB). Three weeks later, they were challenged topically by applying a patch containing 0.01, 0.05, 0.1, 0.5 or 1.0% DNCB. Delayed-type hypersensitivity reaction occurred in both hairless dogs and Beagles. Twenty-four later, erythema developed macroscopically, and epidermal thickening and degeneration and intradermal infiltration of inflammatory cells and vasodilatation were observed microscopically. The total intensity of these changes was dose-dependent and generally weaker in hairless dogs than in Beagles. The present data suggest an existence of slightly depressed cellular immunity in hairless dogs. In addition, such an interesting finding as pigmentation due to deposition of melanin granules was observed in the sites treated with 0.01-0.1% DNCB in hairless dogs.
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