Historical data of neoplastic and non-neoplastic lesions in B6C3F1(C57BL/6CrSlc*C3H/HeSlc) mice.
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Historical data are presented for neoplastic and non-neoplastic lesions in B6C3F1 (C57BL/6×C3H) mice that served as controls for short-term toxicity, long-term toxicity and carcinogenicity studies conducted at the Biosafety Research Center, Foods, Drugs, and Pesticides, (An-Pyo Center) during a 12-yr period (1980-1992). Patterns consistent with spontaneouslly-occurring tumors in specific organs were found in male and female mice and were similar to those reported in the literature. The incidence of most of the neoplastic and non-neoplastic lesions increased with age, suggesting that these pathological alterations are age-associated processes. However, some were believed to be caused by latent viral infections, nutritional or hormone-dependent factors. The wide variety and a high incidence of these lesions seen in long-term studies may greatly complicate histopathological evaluations and the elucidation of treatment-related effects. Consequently, both quantitative and qualitative interpretations are needed for meaningful evaluations.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
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