CHRONIC TOXICITY STUDY OF GARDENIA YELLOW COLOR IN C57BL MICE

概要

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Gardenia yellow (GY) is a widely used natural yellow colorant for foods and clothing. In this study, we have examined the sub-chronic and chronic effects of GY in mice. Both sexes of C57BL/ HeN mice of six weeks old were used. GY was dissolved in distilled water and orally administered. In the sub-chronic study, 0, 0.05, 0.1, 0.2, 0.4, 0.8, and 1.6% of GY were given to mice and they were observed for 12 weeks. During this period, there were no abnormal changes detected in survivals, body weight increases or pathology of organs. It was concluded that GY had no toxicity up to 1.6% in drinking water. The concentrations of 0, 0.2 and 0.8% of GY were chosen for the further carcinogenicity study by observing for 95 weeks. In this chronic toxicity study, there was a 4.5 to 15.4% development of plasmacytoma in the mesenteric lymph nodes that has been known to occur spontaneously in C57BL mice. The pituitary and liver tumors were also noted regardless of the GY doses. The unique observation in this experimental series is the development of hepatosis that is characterized with enlarge-ments of liver, spleen, kidney, and lymph nodes, although they were not related to the doses of GY. These findings were rather systemic and this syndrome may be categorized as amyloidosis. The present study did not show any carcinogenicity or other chronic disorders by GY.
日本毒性病理学会の論文