PUTATIVELY NEGATIVE PROMOTING EFFECT OF FURFURAL ON 2-FAA CHEMICAL HEPATOCARCINOGENESIS IN RATS
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The cancer promoting effect of furfural (C4H3OCHO) was investigated using N-2-fluorenylacetamide (2-FAA) as an initiator. Male Wistar rats, 5 weeks old, were divided into four groups. One group was given three cycles of 0.03% 2-FAA, one cycle consisting of 3 weeks of 0.03% 2-FAA administration and 1 week of basal diet feeding, followed by 16 weeks of furfural administration (20ml/kg basal diet). The other three groups were given 2-FAA only, furfural only, or used as non-treated controls, respectively. Twenty-eight weeks after the end of furfural administration, the animals were killed and histopathological observations including GST-P immunostaining were made. There were no statistically significant differences between the animals given 2-FAA+furfural and the animals given 2-FAA only with regard to the proportion bearing hepatocellular carcinoma (HCC) and the proportion bearing neoplastic nodules. Also, there were no statistically significant differences in the numbers of HCC foci, neoplastic nodules, and GST-P-positive foci per unit area of liver. It is tentatively concluded that furfural does not exert a promoting effect on 2-FAA induced hepatocarcinogenesis in rats. As to our previous findings that furfural-induced hepatic cirrhosis enhanced 2-FAA hepatocarcinogenesis, it is suggested that the morphological distortion of the liver during cirrhotic change, rather than a direct effect of furfural, plays some role in chemical hepatocarcinogenesis.
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