MYOCARDIAL AND HEPATIC NECROSIS AND BONE MARROW SUPPRESSION IN MICE INDUCED BY SINGLE ADMINISTRATION OF CHAETOCHROMIN, A POLYPHENOLIC MYCOTOXIN PRODUCED BY CHAETOMIUM spp
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概要
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A sublethal dose of 140mg/kg b.w. of chaetochromin, a mycotoxin produced by Chaetomium spp, caused lesions in various organs characterized by rather slow-developing necrosis and repair in the ICR male mice. With 3 to 4 days of latent period, focal necrosis of the liver and myocardium and diffuse hematopoietic cell necrosis of the bone marrow were observed histologically. Necrosis also occurred in the spleen, lymph nodes, and thymus but intestinal epithelial cells were not affected. Electron microscopic examination of the heart revealed mitochondrial swelling and degeneration showing myelin-like figures at 3 days, focal and single cell necrosis with disruption of myofibrils at 7 or 8 days. After 11 days calcification developed in necrotic foci of the heart and liver, ensuing foreign body reaction up to 24 days. The bone marrow recovered with no sequelae by 14 to 24 days.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
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