MODULATION OF N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE-INDUCED RAT URINARY BLADDER CARCINOGENESIS BY POST-TREATMENT WITH COMBINATIONS OF THREE PHENOLIC ANTIOXIDANTS
スポンサーリンク
概要
- 論文の詳細を見る
The modifying activities of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and tertiary butylhydroquinone (TBHQ) and of paired combinations of these compounds on urinary bladder carcinogenesis in male F344 rats pretreated with N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) were investigated. Six weeks old animals were given 0.05% BBN in their drinking water for 4 weeks and then BHA, BHT or TBHQ, alone (0.8% each) or in pairs (0.4% each) in their diet for 32 weeks. Control rats received no further treatment after BBN administration. Surviving animals were killed at the end of week 36 of the experiment. The incidence of preneoplastic papillary or nodular hyperplasia (PN hyperplasia) was significantly higher in the group treated with BHA plus TBHQ after treatment with 0.05% BBN than in the group given the initiating carcinogen alone. The densities of PN hyperplasia (number per 10cm of basement membrane) were also significantly increased in all treated groups. However, no synergistic enhancing effects were observed. The incidences and densities of papillomas or carcinomas were not significantly different between any treated group or as compared to the controls. Thus the present experiments indicated that while BHA, BHT, and TBHQ all exerted enhancing effects in BBN-induced urinary bladder carcinogenesis in rats. no synergism regarding this promotion occurs, an important consideration for human risk assessment.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
- Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey
- Latent Infection of Canine Herpes Virus in Laboratory Beagle Dogs
- Age-specific and Dose-dependent Retinal Dysplasia and Degeneration Induced by a Single Intraperitoneal Administration of N-Methyl-N-nitrosourea to Rats
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points