MALIGNANT MELANOMA IN A BDF1 (C57BL/6NCrj×DBA/2NCrj) MOUSE
スポンサーリンク
概要
- 論文の詳細を見る
A melanocytic tumor was found in the skin or subcutaneous tissue in a BDF1 mouse maintained up to 109 weeks. The tumor was solid and well-demarcated from the surrounding tissue, and showed an extensive metastasis to lymph node, liver, and lung. The tumor was composed of both oval or polygonal cells with abundant melanin pigments, and spindle cells mixed with the oval or polygonal cells. These blackish pigments in the tumor cells disappeared by bleaching and more blackened by Fontana-Masson stain. The tumor cell showed poor cellular pleomorphism and rare mitosis. Numerous mature, stage IV-melanosomes were observed in the cytoplasms of the tumor cells by electron-microscopical examination. It was suggested that the origin of the present tumor was a dermal melanocyte by its histological features, though no definite conclusion was obtainable because of ulceration in the central area of the skin covering the nodule.
- 日本毒性病理学会の論文
日本毒性病理学会 | 論文
- Hepatocellular Carcinoma with PIVKA-II Production in a Young Laboratory Monkey
- Latent Infection of Canine Herpes Virus in Laboratory Beagle Dogs
- Age-specific and Dose-dependent Retinal Dysplasia and Degeneration Induced by a Single Intraperitoneal Administration of N-Methyl-N-nitrosourea to Rats
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points